N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Base Information

Chemical Name:N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide
CAS No.:1321562-62-2
Molecular Formula:C₂₆H₁₃Cl₂F₇N₂O₃S
Molecular Weight:637.362
Hs Code.:

Synonyms:N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

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Chemical Property of N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

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Technology Process of N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

There total 5 articles about N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 2786-07-4
2-thienyl lithium

: 1321562-60-0
N-{3-[2,6-dichloro-4-(2,2,2-trifluoroacetyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

: 1321562-62-2
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: In tetrahydrofuran; at -20 ℃; for 2h;

Reference yield:

: 1321562-47-3
1-(4-amino-3,5-dichlorophenyl)-2,2,2-trifluoroethanone

: 1321562-62-2
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / 1,2-dichloro-ethane / 110 °C

2.1: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0 - 80 °C

2.2: pH 8 - 9

3.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C

4.1: tetrahydrofuran / 2 h / -20 °C

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 1321562-56-4
N-[2,6-dichloro-4-(2,2,2-trifluoroacetyl)phenyl]-2-fluoro-3-nitro-benzamide

: 1321562-62-2
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0 - 80 °C

1.2: pH 8 - 9

2.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C

3.1: tetrahydrofuran / 2 h / -20 °C

With hydrogenchloride; sodium hydrogencarbonate; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;