N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Base Information

Chemical Name:N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide
CAS No.:1321561-86-7
Molecular Formula:C₂₆H₁₂Cl₂F₈N₂O₂S
Molecular Weight:639.353
Hs Code.:

Synonyms:N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

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Chemical Property of N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

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Technology Process of N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

There total 6 articles about N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1321562-62-2
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-hydroxy-1-thiophen-2-ylethyl)phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

: 1321561-86-7
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 23516-79-2
4-(trifluoroacetyl)aniline

: 1321561-86-7
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / acetonitrile / 1.5 h / Reflux

2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / 1,2-dichloro-ethane / 110 °C

3.1: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0 - 80 °C

3.2: pH 8 - 9

4.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C

5.1: tetrahydrofuran / 2 h / -20 °C

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; N-chloro-succinimide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; tin(ll) chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1321562-47-3
1-(4-amino-3,5-dichlorophenyl)-2,2,2-trifluoroethanone

: 1321561-86-7
N-{3-[2,6-dichloro-4-(2,2,2-trifluoro-1-fluoro-1-thiophen-2-ylethyl)-phenylcarbamoyl]-2-fluorophenyl}-2,4,6-trifluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / 1,2-dichloro-ethane / 110 °C

2.1: hydrogenchloride; tin(ll) chloride / isopropyl alcohol; water / 0 - 80 °C

2.2: pH 8 - 9

3.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C

4.1: tetrahydrofuran / 2 h / -20 °C

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; tin(ll) chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;