Technology Process of 2-(6-bromo-3,3-diethyl-7-methoxyindolin-1-yl)aniline
There total 4 articles about 2-(6-bromo-3,3-diethyl-7-methoxyindolin-1-yl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-nitrophenyl bromide; 6-bromo-3,3-diethyl-7-methoxyindoline;
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 120 ℃;
for 16h;
Inert atmosphere;
Sealed tube;
With
ammonium chloride; zinc;
In
ethanol;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
1.2: 6 h / 20 °C
2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
2.2: 0.5 h
3.1: sulfuric acid / ethanol / 16 h / 0 - 20 °C
3.2: 0.67 h / -10 - 20 °C
4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 120 °C / Inert atmosphere; Sealed tube
4.2: 4 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
1.2: 0.5 h
2.1: sulfuric acid / ethanol / 16 h / 0 - 20 °C
2.2: 0.67 h / -10 - 20 °C
3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 120 °C / Inert atmosphere; Sealed tube
3.2: 4 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; toluene;
