7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

Base Information

Chemical Name:7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid
CAS No.:1073065-21-0
Molecular Formula:C₄₆H₄₆N₆O₅
Molecular Weight:762.908
Hs Code.:

7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

Synonyms:7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

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Chemical Property of 7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

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Technology Process of 7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

There total 18 articles about 7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: ethyl 7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylate

: 1073065-21-0
7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 30h;
DOI:10.1021/jm501258m

Reference yield:

: 5744-51-4
ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate

: 1073065-21-0
7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2: N-iodo-succinimide; trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

3: phosphorus tribromide / dichloromethane / 3 h / 0 °C

4: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

6: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 24 h / 20 °C

7: lithium hydroxide / tetrahydrofuran; water / 30 h / 20 °C

With N-iodo-succinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; phosphorus tribromide; potassium carbonate; caesium carbonate; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501258m

Reference yield:

: 615-79-2
ethyl 2,4-diketopentanoate

: 1073065-21-0
7-(3-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1-(pyridin-3-ylmethyl)-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: hydrazine hydrate / ethanol / 3 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

4: N-iodo-succinimide; trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

5: phosphorus tribromide / dichloromethane / 3 h / 0 °C

6: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

8: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 24 h / 20 °C

9: lithium hydroxide / tetrahydrofuran; water / 30 h / 20 °C

With N-iodo-succinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; phosphorus tribromide; potassium carbonate; caesium carbonate; hydrazine hydrate; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501258m