(S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate
• CAS No.: 468727-31-3
• Molecular Formula: C₁₉H₂₆N₂O₃
• Molecular Weight: 330.427

Synonyms:(S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property of (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 1 articles about (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate (1261060-18-7) → quinoline (91-22-5) + (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate (468727-31-3) + 2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In acetonitrile; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201004963

Reference yield: 70.0%

benzenesulfonyl chloride (98-09-9) + (S)-tert-butyl 4-((1H-indol-3-yl)methyl)-2,2-dimethyloxazolidine-3-carboxylate (468727-31-3) → C25H30N2O5S (927677-33-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmcl.2009.11.061

upstream raw materials:

(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Downstream raw materials:

C₂₅H₃₀N₂O₅S

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