(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:1261060-18-7
Molecular Formula:C₁₉H₂₄N₂O₃
Molecular Weight:328.411
Hs Code.:

Synonyms:(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

There total 7 articles about (S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1261060-17-6
(S,Z)-tert-butyl 4-(2-formamidostyryl)-2,2-dimethyloxazolidine-3-carboxylate

: 1261060-18-7
(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With pyridine; bis(trichloromethyl) carbonate; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1002/anie.201004963

Reference yield:

: 1261060-16-5
(S)-tert-butyl 4-((2-formamidophenyl)ethynyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1261060-18-7
(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylene dibromide; copper(I) bromide; lithium bromide; zinc / 2,2,2-trifluoroethanol / 3 h / 70 °C / Inert atmosphere

2.1: pyridine; bis(trichloromethyl) carbonate / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: Cooling with ice

With pyridine; bis(trichloromethyl) carbonate; ethylene dibromide; copper(I) bromide; lithium bromide; zinc; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1016/j.tet.2011.05.112

Reference yield:

: 95715-87-0
(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

: 1261060-18-7
(S,Z)-tert-butyl 4-(2-isocyanostyryl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / dichloromethane / 0.67 h / -30 °C / Inert atmosphere

1.2: 2.5 h / -60 - 0 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 2.33 h / 0 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere

4.1: ethylene dibromide; copper(I) bromide; lithium bromide; zinc / 2,2,2-trifluoroethanol / 3 h / 70 °C / Inert atmosphere

5.1: pyridine; bis(trichloromethyl) carbonate / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

5.2: Cooling with ice

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(trichloromethyl) carbonate; ethylmagnesium bromide; ethylene dibromide; triethylamine; triphenylphosphine; copper(I) bromide; lithium bromide; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; 2,2,2-trifluoroethanol; 3.1: Sonogashira coupling;
DOI:10.1016/j.tet.2011.05.112