(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

Base Information

Chemical Name:(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide
CAS No.:1334182-43-2
Molecular Formula:C₃₄H₃₆N₆O₇
Molecular Weight:640.696
Hs Code.:

Synonyms:(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

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Chemical Property of (S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

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Technology Process of (S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

There total 4 articles about (S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 161422-37-3
4-(2-aminoethyl)-1,2-diphendiphenyl-1,2,4-triazolidine-3,5-dione

: 87902-10-1
N^α-(tert-butyloxycarbonyl)-N^δ-phthalimido-L-ornithine

: 1334182-43-2
(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/cmdc.201100241

Reference yield:

: 246146-15-6
C₂₄H₁₈N₄O₄

: 1334182-43-2
(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / tetrahydrofuran; methanol / 16 h

1.2: 2 h / 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C

With benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1002/cmdc.201100241

Reference yield:

: 122-66-7
diphenyl hydrazine

: 1334182-43-2
(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 5 h / Reflux

3.1: hydrazine hydrate / tetrahydrofuran; methanol / 16 h

3.2: 2 h / 20 °C

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C

With potassium tert-butylate; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100241