(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

Base Information

Chemical Name:(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide
CAS No.:1334207-60-1
Molecular Formula:C₅₁H₆₂N₁₀O₇
Molecular Weight:927.116
Hs Code.:

(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

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Chemical Property of (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

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Technology Process of (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

There total 12 articles about (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334182-16-9
C₅₆H₇₀N₁₀O₉

: 1334207-60-1
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201100241

Reference yield:

: 245753-74-6
C₂₆H₃₂N₂O₃

: 1334207-60-1
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 20 °C

2.1: hydrazine hydrate / methanol / 16 h / 20 °C

2.2: 3 h / 20 °C

3.1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; mercury dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201100241

Reference yield:

: 1334182-43-2
(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

: 1334207-60-1
(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nω-ethoxycarbonyl-Nα-{2-(1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]cyclopentyl)acetyl}argininamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 20 °C

3.1: hydrazine hydrate / methanol / 16 h / 20 °C

3.2: 3 h / 20 °C

4.1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; mercury dichloride; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201100241