1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Base Information

Chemical Name:1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline
CAS No.:76786-99-7
Molecular Formula:C₁₈H₂₃NO₂
Molecular Weight:285.386
Hs Code.:

Synonyms:1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Suppliers and Price of 1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

There total 6 articles about 1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 76786-98-6
1-(4-benzyloxybenzyl)-1,2,3,4-tetrahydro-6-methoxy-2-methyl-isoquinoline

: 76786-99-7
1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -65 - -60 ℃; for 2h;
DOI:10.1002/recl.19800991108

Reference yield: 94.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 61273-78-7
1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxyisoquinoline

: 76786-99-7
1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Guidance literature:: With sodium cyanoborohydride; In water; acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1002/recl.19800991108

Reference yield:

: 6547-53-1
2-[4-(benzyloxy)benzyl]acetic acid

: 76786-99-7
1,2,3,4,5,8-hexahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / molecular sieves (3 Angstroem) / xylene / 8 h / Heating

2: POCl₃ / benzene / 1 h / Heating

3: 76 percent / NaBH₄ / ethanol / 1.) 1 h, 0 deg C, 2.) 3 h, room t.

4: 92 percent / H₂ / 5percent Pt/C / H₂O; methanol / 10 h / 45 °C

5: 96 percent / Li/NH₃ (liquid) / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / -65 - -60 °C

With sodium tetrahydroborate; 3 A molecular sieve; ammonia; hydrogen; lithium; trichlorophosphate; platinum on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; xylene; tert-butyl alcohol; benzene;
DOI:10.1002/recl.19800991108