cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

Base Information

Chemical Name:cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione
CAS No.:1352419-37-4
Molecular Formula:C₁₁H₉BrF₃NOS
Molecular Weight:340.164
Hs Code.:

Synonyms:cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

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Chemical Property of cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

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Technology Process of cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

There total 5 articles about cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1352419-36-3
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

: 1352419-37-4
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

Guidance literature:: With tetraphosphorus decasulfide; In tetrahydrofuran; at 20 - 70 ℃; for 1h;

Reference yield:

: 1352126-43-2
rac-2-amino-2-(5-bromo-2,4-difluoro-phenyl)-propionic acid

: 1352419-37-4
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C / pH 10 - 11

2.1: N,N-dimethyl-formamide / 48 h / 110 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

3.2: 0 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 0.33 h / 0 °C

5.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 70 °C

With tetraphosphorus decasulfide; diethylamino-sulfur trifluoride; diisobutylaluminium hydride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1352419-35-2
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-hydroxy-5-methylmorpholin-3-one

: 1352419-37-4
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0.33 h / 0 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 70 °C

With tetraphosphorus decasulfide; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;