cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

Base Information

Chemical Name:cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one
CAS No.:1352419-36-3
Molecular Formula:C₁₁H₉BrF₃NO₂
Molecular Weight:324.097
Hs Code.:

Synonyms:cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

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Chemical Property of cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

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Technology Process of cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

There total 4 articles about cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1352419-35-2
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-hydroxy-5-methylmorpholin-3-one

: 1352419-36-3
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

Guidance literature:: cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-hydroxy-5-methylmorpholin-3-one; With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 0.333333h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 1352126-43-2
rac-2-amino-2-(5-bromo-2,4-difluoro-phenyl)-propionic acid

: 1352419-36-3
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C / pH 10 - 11

2.1: N,N-dimethyl-formamide / 48 h / 110 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

3.2: 0 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 0.33 h / 0 °C

With diethylamino-sulfur trifluoride; diisobutylaluminium hydride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1352419-33-0
rac-2-(5-bromo-2,4-difluorophenyl)-2-(2-chloroacetylamino)propionic acid

: 1352419-36-3
cis/trans-rac-5-(5-bromo-2,4-difluorophenyl)-6-fluoro-5-methylmorpholin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 48 h / 110 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 0.33 h / 0 °C

With diethylamino-sulfur trifluoride; diisobutylaluminium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;