(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

Base Information

Chemical Name:(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one
CAS No.:1000045-31-7
Molecular Formula:C₁₅H₁₈N₂O₆S
Molecular Weight:354.384
Hs Code.:

Synonyms:(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

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Chemical Property of (3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

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Technology Process of (3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

There total 11 articles about (3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1000045-29-3
N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide

: 1000045-31-7
(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃;
DOI:10.3987/COM-11-12224

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1000045-31-7
(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; water / 12 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 °C

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; toluene; 2: Mitsunobu reaction;
DOI:10.3987/COM-11-12224

Reference yield:

: C₁₆H₂₁N₃O₃

: 1000045-31-7
(3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; ethanol / 6 h / 20 °C

2: triethylamine / tetrahydrofuran; water / 12 h / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; 3: Mitsunobu reaction;
DOI:10.3987/COM-11-12224