160239-16-7

Upstream product

• 115437-21-3 7-(triethylsilyl)baccatin III 
• 172213-23-9 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 152448-63-0 2-debenzoyl-2-cyclohexanecarbonyl-7-triethylsilylbaccatin III 
• 160239-15-6 10-O-acetyl2'-O-(tert-butyldimethylsilyl)-2-O-(cyclohexylcarbonyl)-2-debenzoyl-7-O-(triethylsilyl)taxotere 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of nonaromatic taxoids: Effects of alkyl and alkenyl ester groups on cytotoxicity

Several new nonaromatic taxoids are synthesized by means of the β- lactam synthon method. These include taxoids modified with 3-methylbut-2- enoate, 3-methylbutanoate, and cyclohexanecarboxylate groups in place of the benzoate at the C-2 position. In addi

The effect of the aromatic rings of taxol on biological activity and solution conformation: Synthesis and evaluation of saturated taxol and taxotere analogues

The synthesis and biological evaluation of novel cyclohexyl analogues of taxol and taxotere are detailed. 2-(Cyclohexylcarbonyl)-2-debenzoylbaccatin III (6) was prepared from baccatin III by hydrogenation. Subsequent coupling of 6 with N-t-BOC-3-[(tert-bu