3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Base Information

Chemical Name:3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole
CAS No.:1285575-89-4
Molecular Formula:C₂₁H₂₂F₃NO₄S
Molecular Weight:441.471
Hs Code.:

Synonyms:3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

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Technology Process of 3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

There total 12 articles about 3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285575-87-2
3-(3-formyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

: 122-51-0
orthoformic acid triethyl ester

: 1285575-89-4
3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Amberlyst-15; In ethanol; for 3.5h; Reflux;

Reference yield:

: 4433-52-7
2,3-dihydro-benzothiazole

: 1285575-89-4
3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C

2: Amberlyst-15 / ethanol / 3.5 h / Reflux

With N-ethyl-N,N-diisopropylamine; Amberlyst-15; In ethanol; dichloromethane;

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1285575-89-4
3-(3-diethoxymethyl-4-methoxy-5-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.75 h / -70 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran; hexane / 16 h / 60 °C

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: Amberlyst-15 / hexane / 3 h / Reflux

7.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

7.2: 1 h / 0 °C

7.3: 16 h / 20 °C

8.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 6.5 h / 60 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C

10.1: Amberlyst-15 / ethanol / 3.5 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; thionyl chloride; water; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;