methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

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Chemical Name:methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate
CAS No.:1377035-29-4
Molecular Formula:C₄₈H₅₀N₈O₇
Molecular Weight:850.974
Hs Code.:

methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

Synonyms:methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

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Chemical Property of methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

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Technology Process of methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

There total 7 articles about methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1378383-00-6
(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

: 1377035-29-4
methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

Guidance literature:: (S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate; With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid; With COMU; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1378393-20-4
C₁₉H₂₄BrNO₆

: 1377035-29-4
methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

4.1: ammonium acetate / toluene / 3 h / Reflux

5.1: hydrogenchloride / ethanol; water / 1 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

7.2: 0.5 h / 20 °C

With hydrogenchloride; ammonium acetate; hydrogen bromide; sodium acetate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1377035-29-4
methyl (R)-2-((S)-2-(5-(8-(2-((-S)-1-((S)-2-methoxycarbonylainino-3-methylbutanoyl)pyrroIidin-2-yI)-1H-imidazol-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenyIethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

2.1: ammonium acetate / toluene / 3 h / Reflux

3.1: hydrogenchloride / ethanol; water / 1 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen bromide; acetic acid / dichloromethane / 0.5 h / 20 °C

5.2: 0.5 h / 20 °C

With hydrogenchloride; ammonium acetate; hydrogen bromide; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;