(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Chemical Name:(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate
CAS No.:1378382-95-6
Molecular Formula:C₄₄H₄₅BrN₂O₁₁
Molecular Weight:857.752
Hs Code.:

(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Synonyms:(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Chemical Property of (S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Technology Process of (S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

There total 3 articles about (S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1378382-93-4
(S)-2-(2-(4-bromo-3-((methylsulfonyloxy)methyl)phenyl)-2-oxoethyl) 1-tert-butyl pyrrolidine-1,2-dicarboxylate

: 1378382-88-7
(S)-1-benzyl 2-(2-(5-hydroxy-naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 66361-67-9
6-bromo-3,4-dihydro-2H-naphthalen-1-one

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.67 h / 0 - 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 60 °C

3.2: 1 h / 60 °C

3.3: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With n-butyllithium; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane; hexanes; methanol / 12 h / 20 °C

1.2: 122 h / 20 °C

1.3: 2 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2.2: 2 h / -20 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 60 °C

3.2: 1 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With TurboGrignard; caesium carbonate; N-ethyl-N,N-diisopropylamine; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; hexanes; dichloromethane; N,N-dimethyl-formamide; acetonitrile;