(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate
CAS No.:1378383-00-6
Molecular Formula:C₄₆H₄₇N₇O₆
Molecular Weight:793.922
Hs Code.:

(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

Synonyms:(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378393-20-4
C₁₉H₂₄BrNO₆

: 1378383-00-6
(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

4: ammonium acetate / toluene / 3 h / Reflux

5: hydrogenchloride / ethanol; water / 1 h / 60 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; ammonium acetate; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1378382-95-6
(S)-1-benzyl 2-(2-(5-(2-bromo-5-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidine-2-carbonyloxy)acetyl)benzyloxy)naphthalen-2-yl)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 1378383-00-6
(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

2: ammonium acetate / toluene / 3 h / Reflux

3: hydrogenchloride / ethanol; water / 1 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; ammonium acetate; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1378382-93-4
(S)-2-(2-(4-bromo-3-((methylsulfonyloxy)methyl)phenyl)-2-oxoethyl) 1-tert-butyl pyrrolidine-1,2-dicarboxylate

: 1378383-00-6
(S)-benzyl 2-(5-(8-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazoI-5-yl)-6H-dibenzo[c,h]chromen-2-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

3: ammonium acetate / toluene / 3 h / Reflux

4: hydrogenchloride / ethanol; water / 1 h / 60 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; ammonium acetate; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;