2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

Base Information

Chemical Name:2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide
CAS No.:1607801-80-8
Molecular Formula:C₂₀H₁₇BrClF₆NO₂
Molecular Weight:532.708
Hs Code.:

Synonyms:2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

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Chemical Property of 2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

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Technology Process of 2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

There total 2 articles about 2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 449804-01-7
2‐(4‐(butylamino)phenyl)‐1,1,1,3,3,3‐hexafluoropropan‐2‐ol

: 936-08-3
2-bromo-4-chlorobenzoic acid

: 1607801-80-8
2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

Guidance literature:: 2-bromo-4-chlorobenzoic acid; With Vilsmeier reagent; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

2‐(4‐(butylamino)phenyl)‐1,1,1,3,3,3‐hexafluoropropan‐2‐ol; With triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2014.03.007

Reference yield:

: 1126-78-9
N-(n-butyl)aniline

: 1607801-80-8
2-bromo-N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 3 h / 100 °C

2.1: Vilsmeier reagent / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C

With Vilsmeier reagent; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2014.03.007