ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

Base Information

Chemical Name:ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate
CAS No.:691902-73-5
Molecular Formula:C₂₆H₂₆F₂O₃
Molecular Weight:424.487
Hs Code.:

Synonyms:ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

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Chemical Property of ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

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Technology Process of ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

There total 7 articles about ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691905-26-7
2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

: 691902-73-5
ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 6 h / 0 - 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

With sodium tetrahydroborate; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,2-dimethoxyethane; 2: Mitsunobu reaction;
DOI:10.1021/jm101405t

Reference yield:

: C₁₂H₁₂F₂O₃

: 691902-73-5
ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 20 °C

2: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

With platinum(IV) oxide; aluminum (III) chloride; Octanethiol; tributylphosphine; hydrogen; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/jm101405t

Reference yield:

: 691905-10-9
ethyl 3-(2,6-difluoro-4-methoxyphenyl)-propanoate

: 691902-73-5
ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

With aluminum (III) chloride; Octanethiol; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/jm101405t