3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

Base Information

Chemical Name:3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid
CAS No.:691902-74-6
Molecular Formula:C₂₄H₂₂F₂O₃
Molecular Weight:396.434
Hs Code.:

Synonyms:3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

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Chemical Property of 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

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Technology Process of 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

There total 8 articles about 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 691902-73-5
ethyl 3-(2,6-difluoro-4-((2',6'-dimethylbiphenyl-3-yl)methoxy)phenyl)propanoate

: 691902-74-6
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1021/jm101405t

Reference yield:

: C₁₂H₁₂F₂O₃

: 691902-74-6
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 20 °C

2: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

4: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C

With platinum(IV) oxide; aluminum (III) chloride; lithium hydroxide monohydrate; Octanethiol; tributylphosphine; water; hydrogen; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/jm101405t

Reference yield:

: 691905-10-9
ethyl 3-(2,6-difluoro-4-methoxyphenyl)-propanoate

: 691902-74-6
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2,6-difluorophenyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C

With aluminum (III) chloride; lithium hydroxide monohydrate; Octanethiol; tributylphosphine; water; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/jm101405t