Technology Process of 2,6-Difluoro-4-hydroxybenzenepropanoic Acid Ethyl Ester
There total 3 articles about 2,6-Difluoro-4-hydroxybenzenepropanoic Acid Ethyl Ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 3-(2,6-difluoro-4-methoxyphenyl)-propanoate;
With
aluminum (III) chloride; Octanethiol;
In
dichloromethane;
at 0 - 35 ℃;
for 4h;
With
water;
In
dichloromethane;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 20 °C
2: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C
With
platinum(IV) oxide; aluminum (III) chloride; Octanethiol; hydrogen;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm101405t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / Cooling with ice
1.2: 2 h / 20 °C
2.1: platinum(IV) oxide; hydrogen / tetrahydrofuran; ethanol / 20 °C
3.1: aluminum (III) chloride; Octanethiol / dichloromethane / 2 h / 20 °C
With
platinum(IV) oxide; aluminum (III) chloride; Octanethiol; hydrogen; sodium hydride;
In
tetrahydrofuran; ethanol; dichloromethane; mineral oil;
1.1: Horner-Emmons reaction / 1.2: Horner-Emmons reaction;
DOI:10.1021/jm101405t
