cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Base Information

Chemical Name:cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone
CAS No.:1055948-08-7
Molecular Formula:C₂₂H₃₂N₂O
Molecular Weight:340.509
Hs Code.:

Synonyms:cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

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Chemical Property of cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

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Technology Process of cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

There total 6 articles about cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 110-89-4
piperidine

: 1055948-93-0
2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carbaldehyde

: 1055948-08-7
cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Guidance literature:: piperidine; 2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carbaldehyde; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 20h;

With water; sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield:

: 185057-00-5
methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

: 1055948-08-7
cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: potassium hydroxide; water; isopropyl alcohol / 20 h / 80 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2 h / 0 °C

3.2: 16 h / 0 - 20 °C

4.1: manganese(IV) oxide / tetrahydrofuran; chloroform / 16 h / 60 °C

5.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

5.2: 20 h

With manganese(IV) oxide; potassium hydroxide; water; acetic acid; triethylamine; isopropyl alcohol; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; chloroform; 1,2-dichloro-ethane;

Reference yield:

: 1055948-77-0
2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid

: 1055948-08-7
cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: manganese(IV) oxide / tetrahydrofuran; chloroform / 16 h / 60 °C

3.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

3.2: 20 h

With manganese(IV) oxide; acetic acid; triethylamine; isobutyl chloroformate; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane;