3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

Base Information

Chemical Name:3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid
CAS No.:1392842-84-0
Molecular Formula:C₁₉H₁₇N₃O₅
Molecular Weight:367.361
Hs Code.:

Synonyms:3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

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Chemical Property of 3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

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Technology Process of 3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

There total 4 articles about 3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392838-92-4
1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 107-95-9
3-amino propanoic acid

: 1392842-84-0
3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 100-46-9
benzylamine

: 1392842-84-0
3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: triethylamine / methanol / 23 h / Reflux

2.2: 16 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol / 16 h

6.1: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; triethylamine; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392838-84-4
1-benzyl-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

: 1392842-84-0
3-[(1-benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionicacid

Guidance literature:: Multi-step reaction with 4 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

3: sodium methylate / methanol / 16 h

4: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;