3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

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Chemical Name:3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride
CAS No.:1443992-64-0
Molecular Formula:C₃₁H₃₂N₂O₃*ClH
Molecular Weight:517.068
Hs Code.:

Synonyms:3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

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Chemical Property of 3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

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Technology Process of 3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

There total 11 articles about 3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1443993-01-8
(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

: 1443992-64-0
3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

Guidance literature:: zinc(II) cyanide; (3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine; With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium(II) trifluoroacetate; zinc; In N,N-dimethyl acetamide; at 95 ℃; for 3.5h; Inert atmosphere;

With acetic acid; In water; at 20 ℃; for 3h;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: (+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate

: 1443992-64-0
3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 24 h / 20 °C

2.1: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

3.1: palladium(II) trifluoroacetate; zinc; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / N,N-dimethyl acetamide / 3.5 h / 95 °C / Inert atmosphere

3.2: 3 h / 20 °C

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; copper(l) iodide; palladium(II) trifluoroacetate; potassium carbonate; zinc; In N,N-dimethyl acetamide;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1443992-64-0
3-(6-hydroxy-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-3-yl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: polyphosphoric acid / 50 - 75 °C

2.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C

4.1: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 4.5 h / Dean-Stark; Reflux

5.1: tetrahydrofuran / 2.75 h / 0 - 20 °C

6.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 20 °C

7.1: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

8.1: palladium(II) trifluoroacetate; zinc; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / N,N-dimethyl acetamide / 3.5 h / 95 °C / Inert atmosphere

8.2: 3 h / 20 °C

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; piperidine; copper(l) iodide; palladium(II) trifluoroacetate; pyridinium p-toluenesulfonate; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol;