(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Chemical Name:(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine
CAS No.:1443993-01-8
Molecular Formula:C₃₅H₄₀BrNO₄
Molecular Weight:618.611
Hs Code.:

Synonyms:(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Chemical Property of (3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Technology Process of (3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

There total 12 articles about (3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1443992-99-1
3-(3-bromophenyl)-2-(4-iodophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromene

: 620627-27-2
(S)-2-((R)-3-methylpyrrolidin-1-yl)propan-1-ol

: 1443993-01-8
(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: With copper(l) iodide; potassium carbonate; at 125 ℃; Inert atmosphere;

Reference yield:

: 2938-98-9,70423-38-0,101978-85-2,22644-28-6
(R)-2-methylbutane-1,4-diol

: 1443993-01-8
(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / -20 - -15 °C

2: 24 h / 20 °C

3: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1443993-01-8
(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: polyphosphoric acid / 50 - 75 °C

2: boron tribromide / dichloromethane / 0.5 h / 0 °C

3: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C

4: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 4.5 h / Dean-Stark; Reflux

5: tetrahydrofuran / 2.75 h / 0 - 20 °C

6: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 20 °C

7: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

With piperidine; copper(l) iodide; pyridinium p-toluenesulfonate; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; isopropyl alcohol;