(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

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Chemical Name:(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester
CAS No.:1344158-54-8
Molecular Formula:C₂₇H₄₁N₃O₇
Molecular Weight:519.638
Hs Code.:

Synonyms:(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

There total 4 articles about (S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 96-81-1
N-acetyl-L-valine

: 1344158-53-7
(S)-2-((S)-2-amino-3-tert-butoxycarbonyl-propionylamino)-3-methyl-butyric acid benzyl ester

: 1344158-54-8
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 24.0833h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 1352344-80-9
C₃₅H₄₀N₂O₇

: 1344158-54-8
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24.08 h / 0 - 20 °C / Inert atmosphere

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 21760-98-5
L-valine benzyl ester

: 1344158-54-8
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15.08 h / 0 - 20 °C / Inert atmosphere

2: piperidine / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24.08 h / 0 - 20 °C / Inert atmosphere

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.020