(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Chemical Name:(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
CAS No.:1344157-35-2
Molecular Formula:C₃₁H₄₃N₅O₁₀
Molecular Weight:645.71
Hs Code.:

(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Synonyms:(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Chemical Property of (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Technology Process of (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

There total 5 articles about (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 281655-32-1,181824-45-3
(2S,3R)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 1344158-52-6
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid

: C₁₇H₃₀N₅O₄Pol

: 1344157-35-2
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: (2S,3R)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; C₁₇H₃₀N₅O₄Pol; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 20h; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; solid phase reaction;

(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid; Further stages;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 1344158-54-8
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid benzyl ester

: 1344157-35-2
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C / solid phase reaction

2.2: 1 h / 20 °C / solid phase reaction

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 118758-48-8
(2S,3R)-3-phenyl-pyrrolidine-2-carboxylic acid

: 1344157-35-2
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 18.08 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C / solid phase reaction

2.2: 1 h / 20 °C / solid phase reaction

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.020