methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

Base Information

Chemical Name:methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate
CAS No.:1311430-85-9
Molecular Formula:C₃₀H₃₆N₂O₈
Molecular Weight:552.624
Hs Code.:

Synonyms:methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

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Chemical Property of methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

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Technology Process of methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

There total 7 articles about methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1311430-82-6
methyl 3,5-dicyano-4-(8-hydroxynaphthalen-1-yloxy)benzoate

: 1311430-85-9
methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

Guidance literature:: With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; In methanol; at 55 ℃; for 24h; under 33753.4 Torr; Autoclave;
DOI:10.1002/cbic.201100022

Reference yield:

: 1311430-78-0
2-iodo-5-methylisophthalonitrile

: 1311430-85-9
methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium dichromate dihydrate; sulfuric acid / water / 4 h / 0 - 20 °C

2.1: sulfuric acid / 8 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 60 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; platinum(IV) oxide; hydrogen / methanol / 24 h / 55 °C / 33753.4 Torr / Autoclave

With platinum(IV) oxide; sodium dichromate dihydrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cbic.201100022

Reference yield:

: 1311430-80-4
3,5-dicyano-4-iodobenzoic acid

: 1311430-85-9
methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 8 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 60 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; platinum(IV) oxide; hydrogen / methanol / 24 h / 55 °C / 33753.4 Torr / Autoclave

With platinum(IV) oxide; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cbic.201100022