Technology Process of methyl 3,5-dicyano-4-(8-hydroxynaphthalen-1-yloxy)benzoate
There total 5 articles about methyl 3,5-dicyano-4-(8-hydroxynaphthalen-1-yloxy)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,8-dihydroxynaphthalene;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
methyl 3,5-dicyano-4-iodobenzoate;
In
N,N-dimethyl-formamide; mineral oil;
at 60 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1002/cbic.201100022
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dichromate dihydrate; sulfuric acid / water / 4 h / 0 - 20 °C
2.1: sulfuric acid / 8 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
3.2: 0.5 h / 60 °C / Inert atmosphere
With
sodium dichromate dihydrate; sulfuric acid; sodium hydride;
In
water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cbic.201100022
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / water / 1 h / -5 °C
1.2: 0.5 h / 0 °C
1.3: 2 h / 0 - 20 °C
2.1: sodium dichromate dihydrate; sulfuric acid / water / 4 h / 0 - 20 °C
3.1: sulfuric acid / 8 h / Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
4.2: 0.5 h / 60 °C / Inert atmosphere
With
sodium dichromate dihydrate; sulfuric acid; sodium hydride;
In
water; N,N-dimethyl-formamide; mineral oil;
1.2: Sandmeyer reaction / 1.3: Sandmeyer reaction;
DOI:10.1002/cbic.201100022
