2-iodo-5-methylisophthalonitrile

Base Information

Chemical Name:2-iodo-5-methylisophthalonitrile
CAS No.:1311430-78-0
Molecular Formula:C₉H₅IN₂
Molecular Weight:268.057
Hs Code.:

Synonyms:2-iodo-5-methylisophthalonitrile

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Chemical Property of 2-iodo-5-methylisophthalonitrile

Chemical Property:

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Technology Process of 2-iodo-5-methylisophthalonitrile

There total 1 articles about 2-iodo-5-methylisophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 88779-97-9
2-amino-5-methylbenzene-1,3-dicarbonitrile

: 1311430-78-0
2-iodo-5-methylisophthalonitrile

Guidance literature:: 2-amino-5-methylbenzene-1,3-dicarbonitrile; With sulfuric acid; In water; at -5 ℃; for 1h;

With sodium nitrite; In water; at 0 ℃; for 0.5h;

With potassium iodide; In water; at 0 - 20 ℃; for 2h;
DOI:10.1002/cbic.201100022

Reference yield: 70.0%

: 1311430-78-0
2-iodo-5-methylisophthalonitrile

: 1311430-80-4
3,5-dicyano-4-iodobenzoic acid

Guidance literature:: With sodium dichromate dihydrate; sulfuric acid; In water; at 0 - 20 ℃; for 4h;
DOI:10.1002/cbic.201100022

Reference yield:

: 1311430-78-0
2-iodo-5-methylisophthalonitrile

: methyl 3,5-bis((4,5-dihydro-1H-imidazol-2-ylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate dipicrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium dichromate dihydrate; sulfuric acid / water / 4 h / 0 - 20 °C

2.1: sulfuric acid / 8 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 60 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; platinum(IV) oxide; hydrogen / methanol / 24 h / 55 °C / 33753.4 Torr / Autoclave

5.1: methanol; acetyl chloride / 1 h / 0 - 20 °C

6.1: triethylamine / methanol / 1 h / 20 °C

6.2: Reflux

With methanol; platinum(IV) oxide; sodium dichromate dihydrate; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; acetyl chloride; In methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cbic.201100022