tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane

Base Information

• Chemical Name: tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane
• CAS No.: 1388805-83-1
• Molecular Formula: C₂₆H₄₈O₂Si₃
• Molecular Weight: 476.922

Synonyms:tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane

Chemical Property of tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane

There total 2 articles about tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-5-(trimethylsilyl)pent-4-yn-2-ol (1361118-22-0) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane (1388805-83-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jo300169k

Reference yield:

4-(prop-2-enyl)phenol (501-92-8) → tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane (1388805-83-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

With 1H-imidazole; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300169k

Reference yield: 92.0%

tert-butyl(4-(2-((tert-butyldimethylsilyl)oxy)-5-(trimethylsilyl)-pent-4-yn-1-yl)phenoxy)dimethylsilane (1388805-83-1) → 4-(2-((tert-butyldimethylsilyl)oxy)pent-4-yn-1-yl)phenol (1190958-14-5)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 12h;

DOI:10.1021/jo300169k

upstream raw materials:

1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-5-(trimethylsilyl)pent-4-yn-2-ol

tert-butyldimethylsilyl chloride

4-(prop-2-enyl)phenol

Downstream raw materials:

4-(2-((tert-butyldimethylsilyl)oxy)pent-4-yn-1-yl)phenol

1-((tert-butyldimethylsilyl)oxy)-2-(4-oxo-1-(propa-1,2-dien-1-yl)-cyclohexa-2,5-dien-1-yl)ethyl acetate

C₁₉H₂₈I₂O₄Si

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