5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

Base Information

Chemical Name:5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine
CAS No.:1376766-52-7
Molecular Formula:C₂₇H₂₇ClN₆O₄
Molecular Weight:535.002
Hs Code.:

Synonyms:5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

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Chemical Property of 5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

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Technology Process of 5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

There total 3 articles about 5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 7597-14-0
N-(7-chloroquinolin-4-yl)propane-1,3-diamine

: 1376766-58-3
C₁₅H₁₄ClN₃O₄

: 1376766-52-7
5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.ejmech.2012.03.007

Reference yield:

: 1147294-71-0
6-methyl-4-(3-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid isopropyl ester

: 1376766-52-7
5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 105 °C

2: potassium carbonate / tetrahydrofuran / 48 h / 20 °C

With potassium carbonate; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2012.03.007

Reference yield:

: 131275-78-0
Isopropyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1376766-52-7
5-isopropyloxycarbonyl-6-methyl-4-(3-nitrophenyl)-2-[3-(7-chloroquinolin-4-ylamino)propylamino]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 24 h

2: trichlorophosphate / 105 °C

3: potassium carbonate / tetrahydrofuran / 48 h / 20 °C

With potassium carbonate; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2012.03.007