6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine
• CAS No.: 328554-59-2
• Molecular Formula: C₂₁H₁₇ClFN₃O₂S
• Molecular Weight: 429.902
• Mol file: 328554-59-2.mol

Synonyms:6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine

Chemical Property of 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine

There total 3 articles about 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

3-amino-6-chloro-4,5-dimethylpyridazine (76593-36-7) + 2-bromo-2-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)ethanone (183610-69-7) → 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine (328554-59-2)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/jm0009383

Reference yield:

3,6-dichloro-4,5-dimethylpyridazine (34584-69-5) → 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine (328554-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / aq. NH₃ / tetrahydrofuran / 36 h / 150 °C

2: 29 percent / dimethylformamide / 60 °C

With ammonium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0009383

Reference yield:

2-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)ethanone (163304-90-3) → 6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine (328554-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Br₂; AcOH / CH₂Cl₂ / 18 h / 20 °C

2: 29 percent / dimethylformamide / 60 °C

With bromine; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0009383

upstream raw materials:

3-amino-6-chloro-4,5-dimethylpyridazine

2-bromo-2-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)ethanone

3,6-dichloro-4,5-dimethylpyridazine

2-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)ethanone