ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

Base Information

Chemical Name:ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate
CAS No.:152499-74-6
Molecular Formula:C₂₃H₃₄N₂O₈
Molecular Weight:466.532
Hs Code.:

Synonyms:ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

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Chemical Property of ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

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Technology Process of ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

There total 5 articles about ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 152499-69-9
ethyl (RS)-2-(N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

: 152499-74-6
ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; for 16h; Ambient temperature;
DOI:10.1055/s-1993-25947

Reference yield:

: 33884-43-4
2-(2-Bromoethyl)-1,3-dioxane

: 152499-74-6
ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 1.) THF, reflux, 20 min, 2.) THF, -10 deg C to room temp., 1 h

2: 58 percent / hexane / 3 h / Heating

3: 98 percent / NaCNBH₃ / acetonitrile; acetic acid / 24 h

4: 74 percent / 1N NaHCO₃ / dioxane; H₂O / 16 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; magnesium; In 1,4-dioxane; hexane; water; acetic acid; acetonitrile;
DOI:10.1055/s-1993-25947

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 152499-74-6
ethyl (RS)-2-(N-benzyloxycarbonyl-N'-tert-butoxycarbonylhydrazino)-5,5-(1,3-propanediyldioxy)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / hexane / 3 h / Heating

2: 98 percent / NaCNBH₃ / acetonitrile; acetic acid / 24 h

3: 74 percent / 1N NaHCO₃ / dioxane; H₂O / 16 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; In 1,4-dioxane; hexane; water; acetic acid; acetonitrile;
DOI:10.1055/s-1993-25947