tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

Base Information

Chemical Name:tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate
CAS No.:32719-57-6
Molecular Formula:C₃₉H₆₁N₃O₁₂
Molecular Weight:763.926
Hs Code.:

tetra-tert-butyl N-<N-<N-(benzyloxycarbonyl)-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Synonyms:tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

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Chemical Property of tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

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Technology Process of tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

There total 9 articles about tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 88063-78-9
L-γ-glutamyl-L-glutamic acid tris-t-butyl ester

: 34897-61-5
N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt

: 32719-57-6
tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

Guidance literature:: With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 16h;
DOI:10.1002/jhet.5570270654

Reference yield: 69.0%

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 88063-78-9
L-γ-glutamyl-L-glutamic acid tris-t-butyl ester

: 32719-57-6
tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

Guidance literature:: (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 10 - 20 ℃; for 0.5h; Large scale;

L-γ-glutamyl-L-glutamic acid tris-t-butyl ester; In dichloromethane; at 20 ℃; for 20h; Large scale;

Reference yield:

: 32719-56-5
tri-tert-butyl N--L-glutamate

: 32719-57-6
tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol

2: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00121a029