1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

Base Information

Chemical Name:1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine
CAS No.:1357262-67-9
Molecular Formula:C₂₃H₂₂N₄
Molecular Weight:354.454
Hs Code.:

Synonyms:1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

Chemical Property:

Purity/Quality:

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Technology Process of 1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

There total 5 articles about 1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1357263-11-6
{1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-67-9
1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1357263-05-8
6-chloro-7-phenyl-imidazo[1,2-b]pyridazine

: 1357262-67-9
1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.67 h / 100 °C / Microwave irradiation

4: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; chloroform;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-67-9
1-[4-(3-methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.67 h / 100 °C / Microwave irradiation

4: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; chloroform;