N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1313409-78-7
Molecular Formula:C₂₇H₂₂IN₇O₂
Molecular Weight:603.422
Hs Code.:

Synonyms:N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

There total 9 articles about N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₈H₅ClN₂O*(x)ClH

: 1313409-77-6
3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

: 1313409-78-7
N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: C₈H₅ClN₂O*(x)ClH; 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine; In tetrahydrofuran; 1,2-dichloro-ethane; at 80 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 1313409-78-7
N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

1.2: 0 °C / Molecular sieve

2.1: thionyl chloride / dichloromethane / 3 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

4.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

4.2: 0.5 h / Reflux

5.1: tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 80 °C

5.2: 20 °C

With lithium aluminium tetrahydride; thionyl chloride; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 885521-22-2
3-iodo-4-nitro-1H-indazole

: 1313409-78-7
N-(3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

2.2: 0.5 h / Reflux

3.1: tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 80 °C

3.2: 20 °C

With iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;