3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

Base Information

Chemical Name:3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine
CAS No.:1313409-77-6
Molecular Formula:C₁₉H₁₈IN₅O
Molecular Weight:459.289
Hs Code.:

Synonyms:3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

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Chemical Property of 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

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Technology Process of 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

There total 7 articles about 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313409-75-4
3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-4-nitro-1H-indazole

: 1313409-77-6
3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

Guidance literature:: 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-4-nitro-1H-indazole; With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 3h;

With triethylamine; In ethyl acetate; for 0.5h; Reflux;

Reference yield:

: 885521-22-2
3-iodo-4-nitro-1H-indazole

: 1313409-77-6
3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

2.2: 0.5 h / Reflux

With iron; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1313409-77-6
3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2.2: 0 °C / Molecular sieve

3.1: thionyl chloride / dichloromethane / 3 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

5.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

5.2: 0.5 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;