6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

Base Information

Chemical Name:6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one
CAS No.:357269-94-4
Molecular Formula:C₁₆H₁₆N₂O₃S
Molecular Weight:316.381
Hs Code.:

Synonyms:6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

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Technology Process of 6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

There total 6 articles about 6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 96-34-4
methyl chloroacetate

: 219806-93-6
5-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine

: 357269-94-4
6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

Guidance literature:: With triethylamine; In toluene; for 4h; Reflux;
DOI:10.1134/S1070428009080296

Reference yield: 79.0%

: 79-11-8
chloroacetic acid

: 219806-93-6
5-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine

: 357269-94-4
6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

Guidance literature:: In neat (no solvent); for 0.25h; regioselective reaction; Heating;
DOI:10.3762/bjoc.9.78

Reference yield: 42.0%

: 105-39-5
chloroacetic acid ethyl ester

: 219806-93-6
5-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine

: 357269-94-4
6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one

Guidance literature:: chloroacetic acid ethyl ester; 5-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine; at 110 - 115 ℃; for 0.5h;

With ammonia; In ethanol; pH=7.5 - 8;
DOI:10.1016/j.tetlet.2018.02.014