219806-93-6

Upstream product

• 113697-57-7 5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione 
• 17356-08-0 thiourea 
• 123-54-6 acetylacetone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 357269-94-4 6-acetyl-7-methyl-5-(4-methoxyphenyl)-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one 
• 292873-86-0 6-acetyl-5-(2,4-dimethoxyphenyl)-7-methyl-2H-thiazolo[3,2-a]pyrimidine-3(5H)-one 
• 1400767-17-0 C₃₁H₂₆N₂O₂S 
• 1400767-18-1 C₃₁H₂₄Cl₂N₂O₂S 
• 1400767-19-2 C₃₁H₂₄F₂N₂O₂S 
• 1400767-20-5 C₃₃H₂₆N₂O₆S 
• 1400767-21-6 C₂₇H₂₂N₂O₂S₃ 
• 1408331-75-8 2-((5-acetyl-6-methyl-4-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrimidine-2yl)sulfanyl)acetic acid 
• 1408331-82-7 C₁₇H₁₆N₄OS 
• 1408331-91-8 1-(6-methyl-4-(4-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5yl)-3-(2-methoxyphenyl)prop-2en-1-one 
• 1408331-95-2 5-(5-(2-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)-6-methyl-4-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrimidine-2(1H)-thione 
• 1425352-72-2 6-acetyl-5-(4-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one hydrochloride 
• 851232-26-3 C₁₄H₁₆N₂O₂S 
• 851232-27-4 C₁₄H₁₆N₂O₂S 

Relevant academic research and scientific papers

Bronsted acidic ionic liquid based magnetic nanoparticles: A new promoter for the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

The Bronsted acidic ionic liquid 1-methyl-3-(3- trimethoxysilylpropyl) imidazolium hydrogen sulfate was immobilized on magnetic Fe3O4 nanoparticles (MNPs-IL-HSO4). The properties of the magnetic nanocatalyst were character

A novel synthesis and characterization of 1,2,3,4-tetrahydropyrimidin-2(1H)-thiones

We reported the use of Br?nsted acid methane sulfonic acid as a promoter for three component Biginelli cyclocondensation reaction of aryl aldehydes, acetylacetone and thiourea at 120°C to afford the corresponding to 1,2,3,4-tetrahydropyrimidin-2(1H)-thion

CoNiFe2O4@Silica-SO3H nanoparticles: New recyclable magnetic nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions

A useful and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were achieved by one-pot cyclocondensation between substituted aryl aldehydes, diketone/ketoester, and urea/thiourea using magnetic CoNiFe2O4@Silica-

SnO2 nanoparticles: An efficient reusable heterogeneous catalyst for synthesis of 3,4-dihydropyrimidinones under solvent-free conditions

Some 3,4-dihydropyrimidine derivatives have been synthesized from the reaction of divergent aldehydes with acetylacetone and urea/thiourea using nano tin oxide nanoparticles under solvent-free condition. The nanoparticle catalyst used in this synthesis is

Efficient Catalytic Synthesis of 3,4-Dihydropyrimidin-2-ones/thiones via Little Acidic Ionic Liquid Combined with Rapid Heating Ways

Catalytic synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was efficiently promoted by as little as 2.5?mol% of Br?nsted acidic ionic liquid [(CH2)3SO3HMIM]HSO4 catalyst loading via rapid heating ways. Inter

Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition

A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high

Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety

A series of dihydropyrimidine (DHPM) derivatives bearing 1,3,4-oxadiazole moiety was designed and synthesized as monastrol analogues. The new compounds were screened for their cytotoxic activity toward 60 cancer cell lines according to NCI (USA) protocol. Seven compounds were further examined against the most sensitive cell lines, leukemia HL-60(TB) and MOLT-4. The most active compounds were 9m against HL-60(TB) (IC50 = 56 nM) and 9n against MOLT-4 (IC50 = 80 nM), more potent than monastrol (IC50 = 147 and 215 nM, respectively). Cell cycle analysis of HL-60(TB) cells treated with 9m and MOLT-4 cells treated with 9n showed cell cycle arrest at G2/M phase and pro-apoptotic activity as indicated by annexin V-FITC staining.

Polymer-supported benzimidazolium based ionic liquid: An efficient and reusable Br?nsted acid catalyst for Biginelli reaction

A polymer-supported benzimidazolium based ionic liquid (PSBIL) was synthesized by reaction of poly(vinylbenzyl chloride) and benzimidazole followed by ring opening of 1,4-butane sultone and acidification with sulphuric acid. The resulting Br?nsted acid he

Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

A series of tetrahydropyrimidinethiones were synthesized from thiourea, β-diketones and aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde, salicylaldehyde and benzaldehyde. These cyclic thioureas showed good inhibitory action agai

Benzyltriphenylphosphonium chloride: An efficient catalyst for one-pot synthesis of dihydropyrimidinones/thiones under solvent-free conditions

An efficient and one-pot method for the preparation of 3,4-dihydropyrimidin-2(1H)-ones/thiones is described. Benzyltriphenylphosphonium chloride (BTPPC) under solvent free conditions catalyzes this multi-component condensation reaction to afford the corre