N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine

Base Information

• Chemical Name: N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine
• CAS No.: 1609963-02-1
• Molecular Formula: C₁₃H₁₆F₂N₄O₂S
• Molecular Weight: 330.358

Synonyms:N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine

Chemical Property of N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine

There total 7 articles about N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

diethyl (bromodifluoromethyl)phosphonate (65094-22-6) + N′-[2-cyano-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine (1609962-99-3) → N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine (1609963-02-1)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at -78 - 20 ℃; for 2h;

Reference yield:

2-amino-4-bromo-6-fluoro-benzonitrile (1279865-14-3) → N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine (1609963-02-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,1-dimethoxyethane / 2 h / 120 °C

2: caesium carbonate / 1,4-dioxane / 48 h / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 2 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: potassium hydroxide / acetonitrile; water / 2 h / -78 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1-dimethoxyethane; caesium carbonate; trifluoroacetic acid; potassium hydroxide; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine (1609963-00-9) → N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine (1609963-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 2 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: potassium hydroxide / acetonitrile; water / 2 h / -78 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluoroacetic acid; potassium hydroxide; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; water; acetonitrile;

upstream raw materials:

2-amino-4-bromo-6-fluoro-benzonitrile

4-bromo-2,6-difluorobenzonitrile

N'-(5-bromo-2-cyano-3-fluoro-phenyl)-N,N-dimethyl-formamidine

diethyl (bromodifluoromethyl)phosphonate

Downstream raw materials:

C₂₁H₂₁F₃N₄O₄S

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