1279865-14-3

Basic information

• Product Name: 2-aMino-4-broMo-6-fluorobenzonitrile
• Synonyms: 2-aMino-4-broMo-6-fluorobenzonitrile
• CAS NO: 1279865-14-3
• Molecular Formula: C₇H₄BrFN₂
• Molecular Weight: 215.0224632
• Mol File: 1279865-14-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 314.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.77±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.27±0.10(Predicted)
• CAS DataBase Reference: 2-aMino-4-broMo-6-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-4-broMo-6-fluorobenzonitrile(1279865-14-3)
• EPA Substance Registry System: 2-aMino-4-broMo-6-fluorobenzonitrile(1279865-14-3)

Safety Data

• Hazardous Substances Data: 1279865-14-3(Hazardous Substances Data)

Usage

General Description

2-Amino-4-bromo-6-fluorobenzonitrile is a chemical compound with the molecular formula C7H4BrFN2. It is a yellow solid that is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. 2-aMino-4-broMo-6-fluorobenzonitrile is known for its potential application as a building block in the development of new medicines, particularly as a component in the synthesis of biologically active molecules. It is also used in organic and medicinal chemistry research as a versatile starting material for the preparation of a wide range of heterocyclic compounds. Additionally, it has been studied for its potential as an anticancer and antiviral agent, making it an important compound in the field of drug discovery and development.

Upstream product

• 123843-67-4 4-bromo-2,6-difluorobenzonitrile 

Downstream Products

• 1609962-87-9 N'-(5-bromo-2-cyano-3-fluoro-phenyl)-N,N-dimethyl-formamidine 
• 1609963-02-1 N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine 
• 1609962-93-7 N'-(5-bromo-2-cyano-3-methoxyphenyl)-N,N-dimethylformamidine 
• 1609960-67-9 C₂₁H₂₁F₃N₄O₄S 
• 1609960-66-8 C₂₀H₂₁FN₄O₄S 
• 1609963-01-0 N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine 
• 1609963-00-9 N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine 
• 1609962-99-3 N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine 

Relevant articles and documents

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS

This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I wherein Ar, R1 and R2 are as defined in the description and claims, and their use as MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of MNK1 (MNK1a or MNK1b) and/or MNK2 (MNK2a or MNK2b) mediated disorders.