(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

Base Information

Chemical Name:(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate
CAS No.:220825-77-4
Molecular Formula:C₂₂H₂₄F₂O₄
Molecular Weight:390.427
Hs Code.:

Synonyms:(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

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Chemical Property of (+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

Chemical Property:

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Technology Process of (+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

There total 5 articles about (+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1895-39-2
sodium chlorodifluoroacetate

: 220825-76-3
4-benzyloxy-3-benzyloxymethyl-2-butenyl acetate

: 220825-77-4
(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

Guidance literature:: In diethylene glycol dimethyl ether; at 190 ℃; for 1h;
DOI:10.1016/S0040-4020(98)01067-9

Reference yield:

: 6972-79-8
dibenzyl glycerol

: 220825-77-4
(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / 2,2,6,6-tetramethyl-piperidin-1-oxyl radical (TEMPO); KBr; NaOCl / CH₂Cl₂; H₂O / 1 h / 10 - 15 °C

2: 82 percent / NaH / various solvent(s)

3: 85 percent / diisobutyl aluminium hydride (DIBAH) / toluene / -40 °C

4: 84 percent / pyridine / 4 h / 25 °C

5: 75 percent / bis-(2-methoxy-ethyl) ether / 1 h / 190 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydride; diisobutylaluminium hydride; potassium bromide; In pyridine; dichloromethane; diethylene glycol dimethyl ether; water; toluene; 1: Oxidation / 2: Wittig-reaction / 3: Alcohol formation / 4: Acetylation / 5: Cycloaddition;
DOI:10.1016/S0040-4020(98)01067-9

Reference yield:

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 220825-77-4
(+/-)-(1 RS)-[2,2-di(benzyloxymethyl)-3,3-difluorocyclopropyl]-methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / NaH / various solvent(s)

2: 85 percent / diisobutyl aluminium hydride (DIBAH) / toluene / -40 °C

3: 84 percent / pyridine / 4 h / 25 °C

4: 75 percent / bis-(2-methoxy-ethyl) ether / 1 h / 190 °C

With sodium hydride; diisobutylaluminium hydride; In pyridine; diethylene glycol dimethyl ether; toluene; 1: Wittig-reaction / 2: Alcohol formation / 3: Acetylation / 4: Cycloaddition;
DOI:10.1016/S0040-4020(98)01067-9