77356-14-0Relevant articles and documents
Method for preparing 1,3-dibenzyloxy-2-acetone
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Paragraph 0036-0051, (2021/03/10)
The invention discloses a method for preparing 1,3-dibenzyloxy-2-acetone. The method comprises the following steps: carrying out nucleophilic reaction on benzyl alcohol and epoxy chloropropane in an alkaline aqueous solution, washing the nucleophilic reaction mixture with water, carrying out primary extraction by using a first extractant to obtain an organic layer, drying the organic layer for thefirst time, distilling under reduced pressure to remove fractions below 175 DEG C/5 mm Hg to obtain an intermediate product, adding a solvent, phosphorus pentoxide and dimethyl sulfoxide into the intermediate product under the conditions of inert atmosphere and ice-water bath, keeping the inert atmosphere, heating to room temperature, reacting, keeping the inert atmosphere, adding organic amine under the condition of ice-water bath, keeping the inert atmosphere, heating to room temperature, and continuously reacting to generate the 1,3-dibenzyloxy-2-acetone. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, simple operation and high yield.
N-[2-(2-AMINO-6,6-DISUBSTITUTED-4, 4A, 5, 6-TETRAHYDROPYRANO [3,4-D][1,3] THIAZIN-8A (8H)-YL) -1, 3-THIAZOL-4-YL] AMIDES
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Page/Page column 87; 88; 89, (2017/04/11)
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variables R1, R2 and R3
Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition
Ryabtsova, Oksana,Joossens, Jurgen,Van Der Veken, Pieter,Vanden Berghe, Wim,Augustyns, Koen,De Winter, Hans
, p. 5032 - 5038 (2016/10/05)
The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.
Efficient aerobic oxidation of secondary alcohols at ambient temperature with an ABNO/NOx catalyst system
Lauber, Markus B.,Stahl, Shannon S.
, p. 2612 - 2616 (2013/11/19)
New highly practical methods are presented for aerobic oxidation of secondary alcohols with a nitroxyl radical in combination with HNO3, NaNO2, or both as cocatalysts. Diverse nitroxyls are compared, including several novel bicyclic derivatives. Catalyst systems with the readily available nitroxyls, 9-azabicyclo[3.3.1]nonane-N-oxyl (ABNO) and 9-azabicyclo[3.3.1]nonan-3-one-N-oxyl (keto-ABNO), are optimized in acetic acid or acetonitrile as the solvent. The reactions are compatible with substrates bearing diverse functional groups and proceed efficiently under mild conditions at ambient pressure and temperature.
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo
Martic, Miljen,Pernot, Lucile,Westermaier, Yvonne,Perozzo, Remo,Kraljevic, Tatjana Gazivoda,Kristafor, Svjetlana,Raic-Malic, Silvana,Scapozza, Leonardo,Ametamey, Simon
experimental part, p. 293 - 315 (2012/02/03)
Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is
Methoxymethyl (MOM) group nitrogen protection of pyrimidines bearing C-6 acyclic side-chains
Kraljevic, Tatjana Gazivoda,Petrovic, Martina,Kristafor, Svjetlana,Makuc, Damjan,Plavec, Janez,Ross, Tobias L.,Ametamey, Simon M.,Raic-Malic, Silvana
scheme or table, p. 5113 - 5129 (2011/08/06)
Novel N-methoxymethylated (MOM) pyrimidine (4-13) and pyrimidine-2,4- diones (15-17) nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized. Synthetic methods via O-persilylated or N-a
Syntheses and antitumor evaluation of C(6)-isobutyl- and C(6)-isobutenyl-substituted pyrimidines, and dihydropyrrolo[1,2-c]pyrimidine-1, 3-diones
Kristafor, Svjetlana,Kraljevic, Tatjana Gazivoda,Ametamey, Simon M.,Cetina, Mario,Ratkaj, Ivana,Hacek, Romana Tandara,Pavelic, Sandra Kraljevic,Raic-Malic, Silvana
experimental part, p. 1455 - 1469 (2011/11/05)
A growing body of evidence supports that pyrimidine derivatives, in which the sugar residues have been replaced by acyclic side chains, might be developed as promising anticancer agents that interfere with tumor cell proliferation, survival, and metastati
PROCESS FOR PREPARING PURINE DERIVATIVE
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Page/Page column 6, (2010/06/16)
A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.
INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 44-45, (2009/05/28)
The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture o
INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 42, (2009/05/28)
The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture o
