2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Base Information

Chemical Name:2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde
CAS No.:1132765-73-1
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

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Chemical Property of 2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

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Technology Process of 2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

There total 6 articles about 2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-4-ol

: 1132765-73-1
2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1002/cmdc.202000762

Reference yield:

: 696-62-8
para-iodoanisole

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1132765-73-1
2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Guidance literature:: With potassium phosphate; copper(l) iodide; In ethylene glycol; isopropyl alcohol; at 85 - 90 ℃; for 36h; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201604750

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1132765-73-1
2-(6,7-dimethoxy-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium diacetoxy(acetyl)boranuide / chloroform / 1 h / 20 °C

1.2: 8 h / 20 °C

2.1: hydrogenchloride / water / 1 h / 20 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium diacetoxy(acetyl)boranuide; trifluoroacetic acid; In dichloromethane; chloroform; water;
DOI:10.1002/cmdc.202000762