N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

Base Information

Chemical Name:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea
CAS No.:1311298-59-5
Molecular Formula:C₄₃H₅₁N₃O₅Si
Molecular Weight:717.981
Hs Code.:

Synonyms:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

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Chemical Property of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

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Technology Process of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

There total 11 articles about N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: (6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanamine

: 1311298-57-3
3-(4,4'-dimethoxytrityloxymethyl)benzylamine

: 530-62-1
1,1'-carbonyldiimidazole

: 1311298-59-5
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

Guidance literature:: 3-(4,4'-dimethoxytrityloxymethyl)benzylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanamine; In tetrahydrofuran; for 48h;

Reference yield:

: (6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanamine

: 1311299-11-2
C₃₃H₃₁N₃O₄

: 1311298-59-5
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.05.046

Reference yield:

: 1311298-52-8
2-azidomethyl-6-tertbutyldimethylsilyloxymethylpyridine

: 1311298-59-5
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 5 h / 20 °C

2.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.2: 48 h

With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; methanol;