N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

Base Information

Chemical Name:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea
CAS No.:1311298-61-9
Molecular Formula:C₃₇H₃₇N₃O₅
Molecular Weight:603.718
Hs Code.:

Synonyms:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

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Chemical Property of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

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Technology Process of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

There total 10 articles about N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1311298-59-5
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]urea

: 1311298-61-9
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 150058-64-3
(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanol

: 1311298-61-9
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triethylamine; sodium azide; triphenylphosphine / N,N-dimethyl-formamide / 25 h / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 5 h / 20 °C

3.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.2: 48 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1195-59-1
2.6-bis(hydroxymethyl)pyridine

: 1311298-61-9
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 12 h

2.1: carbon tetrabromide; triethylamine; sodium azide; triphenylphosphine / N,N-dimethyl-formamide / 25 h / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 5 h / 20 °C

4.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4.2: 48 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;