Technology Process of methyl 2-(dibenzylamino)-3-(3,4-dimethoxyphenyl)propanoate
There total 2 articles about methyl 2-(dibenzylamino)-3-(3,4-dimethoxyphenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-dibenzylaminopropionic acid methyl ester;
With
lithium dicyclohexylamide;
In
toluene;
at 0 ℃;
for 0.25h;
Inert atmosphere;
4-Bromoveratrole;
With
bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0); 2-(2-(dicyclohexylphosphino)-1H-imidazol-1-yl)-N,N-dimethylaniline;
In
toluene;
at 70 ℃;
for 16h;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201206237
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 20 h / Inert atmosphere; Reflux
2.1: lithium dicyclohexylamide / toluene / 0.25 h / 0 °C / Inert atmosphere
2.2: 16 h / 70 °C / Inert atmosphere
With
sodium hydrogencarbonate; lithium dicyclohexylamide;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1002/anie.201206237
- Guidance literature:
-
methyl 2-(dibenzylamino)-3-(3,4-dimethoxyphenyl)propanoate;
With
Pd(OH)2/C; hydrogen; acetic acid;
In
methanol; water;
at 20 ℃;
for 15h;
under 30003 Torr;
Autoclave;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
pH=8;
Inert atmosphere;
DOI:10.1002/anie.201206237
