DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester

Base Information

• Chemical Name: DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester
• CAS No.: 112302-87-1
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Mol file: 112302-87-1.mol

Synonyms:

Chemical Property of DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester

There total 8 articles about DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dibenzyl-O-benzoylhydroxylamine (52742-32-2) + [1-methoxyprop-1-enyloxy]trimethylsilane (34880-70-1) → 2-dibenzylaminopropionic acid methyl ester (112302-87-1)

Guidance literature:

With 1,5-bis-(diphenylphosphino)pentane; copper diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1002/anie.201206755

Reference yield: 83.0%

methyl 2-aminopropanoate monohydrochloride (13515-97-4) + benzyl bromide (100-39-0) → 2-dibenzylaminopropionic acid methyl ester (112302-87-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; dimethyl sulfoxide; for 20h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201206237

Reference yield: 80.0%

(dibenzylamino)acetic acid methyl ester (94226-55-8) + methyl iodide (74-88-4) → 2-dibenzylaminopropionic acid methyl ester (112302-87-1)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1039/c39870001329

upstream raw materials:

methanol

N,N-dibenzylalanine

(dibenzylamino)acetic acid methyl ester

methyl iodide

Downstream raw materials:

(2S,3R)-2-Dibenzylamino-3-heptyl-2-methyl-pentanedioic acid 5-ethyl ester 1-methyl ester

(2S,3R)-2-Dibenzylamino-2,3-dimethyl-pentanedioic acid dimethyl ester

(2S,3R)-2-Dibenzylamino-2,3-dimethyl-pentanedioic acid 5-tert-butyl ester 1-methyl ester

3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-one