2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

Base Information

Chemical Name:2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone
CAS No.:863888-39-5
Molecular Formula:C₁₉H₂₅ClN₂O₃
Molecular Weight:364.872
Hs Code.:

Synonyms:2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

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Chemical Property of 2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

Chemical Property:

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Technology Process of 2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

There total 3 articles about 2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 863888-49-7
4-(4-hydroxymethylphenyl)butan-2-ol

: 88093-48-5
2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone

: 863888-39-5
2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm701443n

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 863888-39-5
2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; triphenylphosphine; palladium diacetate / 75 °C / Inert atmosphere

2: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium diacetate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 74248-99-0
methyl 2-(4-methoxycarbonylphenyl)ethyl ketone

: 863888-39-5
2-tert-butyl-4-chloro-5-[4-(3-hydroxybutyl)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran;